Complete Bibliography

Periman LM, Lappin CJ, McDonald MB, et al. Improvement in Visual-Tasking Daily Living Activities and Work Productivity in Patients with Dry Eye Disease: Integrated Analysis of COMET Studies. Ophthalmol Ther. Published online July 18, 2026. doi:10.1007/s40123-026-01421-1

Periman LM, Lindstrom R, Karpecki P, et al. Using Lotilaner Ophthalmic Solution, 0.25% to Treat Demodex Blepharitis in Patients Who Were Initially Misdiagnosed: A Case Series. Clin Optom (Auckl). 2026;18:600893. Published 2026 Jun 24. doi:10.2147/OPTO.S600893

Karpecki P, Ayres B, Donnenfeld E, et al. Lotilaner ophthalmic solution 0.25% in the treatment of Demodex blepharitis: A case report. SAGE Open Med Case Rep. 2026;14:2050313X261443128. Published 2026 Apr 20. doi:10.1177/2050313X261443128

Johnston J, Adler R, Hessen M, et al. Effect of Cyclosporine Ophthalmic Solution 0.09% on Signs and Symptoms of Dry Eye Disease in Patients Inadequately Controlled on Cyclosporine Ophthalmic Emulsion 0.05%: Results from a Single-Arm, Open-Label, Phase 4 Study. Clin Ophthalmol. 2026;20:583071. Published 2026 Mar 4. doi:10.2147/OPTH.S583071

Abbott KS, Echharam RJ, Periman LM. Neuromodulation with Botulinum Toxin in Eyelid-Associated Ocular Surface Disease. J Vis Exp. 2025;(224):10.3791/68659. Published 2025 Oct 10. doi:10.3791/68659

Tong L, Liu Z, Şahin A, et al. Topical pharmacologic treatments for dry eye disease: A systematic review. Ocul Surf. 2025;38:302-317. doi:10.1016/j.jtos.2025.07.010

Tichenor AA, Zimski L, Periman LM. Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases. J Vis Exp. 2025;(221):10.3791/68377. Published 2025 Jul 3. doi:10.3791/68377

Donnenfeld E, Nichols KK, Ayres BD, et al. The Demodex Expert Panel on Treatment and Eyelid Health (DEPTH) Consensus Regarding the Preferred Treatment for Demodex Blepharitis. Clin Ophthalmol. 2025;19:1893-1904. Published 2025 Jun 18. doi:10.2147/OPTH.S525681

Periman LM, Whitley WO, Maiti S, et al. The patient journey and burden of disease in Demodex blepharitis in the United States. J Med Econ. 2025;28(1):734-742. doi:10.1080/13696998.2025.2500224

Maiti S, Kondapalli SSA, Periman LM. Recalcitrant Dry Eye Disease in a 31-Year-Old Female: Favorable Outcomes Following Complete Ocular Lavage Facilitated by an Irrigating Eyelid Retractor. Cureus. 2025;17(2):e78554. Published 2025 Feb 5. doi:10.7759/cureus.78554

Yeu E, Paauw JD, Vollmer P, et al. Safety and Efficacy of Lotilaner Ophthalmic Solution (0.25%) in Treating Demodex Blepharitis: Pooled Analysis of Two Pivotal Trials. Ophthalmol Ther. 2025;14(3):555-571. doi:10.1007/s40123-024-01089-5

Periman LM, White DE, Katsev D. Differentiating Between Perfluorohexyloctane Ophthalmic Solution and Water-Free Cyclosporine Ophthalmic Solution 0.1% for Dry Eye Disease: A Review of Preclinical and Clinical Characteristics. Ophthalmol Ther. 2025;14(2):283-293. doi:10.1007/s40123-024-01076-w

Donnenfeld E, Coats J, Barbour K, Ryan R, Joshi NR, Periman LM. Efficacy and safety of a lipid-containing artificial tear compared with a non-lipid containing tear: a randomized clinical trial. BMC Ophthalmol. 2024;24(1):442. Published 2024 Oct 8. doi:10.1186/s12886-024-03688-z

Gioia N, Gerson J, Ryan R, et al. A novel multi-ingredient supplement significantly improves ocular symptom severity and tear production in patients with dry eye disease: results from a randomized, placebo-controlled clinical trial. Front Ophthalmol (Lausanne). 2024;4:1362113. Published 2024 Apr 24. doi:10.3389/fopht.2024.1362113

Barnett M, Simmons B, Vollmer P, et al. The impact of Demodex blepharitis on patient symptoms and daily life. Optom Vis Sci. 2024;101(3):151-156. doi:10.1097/OPX.0000000000002111

Katz J, Periman LM, Maiti S, et al. Bilateral Effect of OC-01 (Varenicline Solution) Nasal Spray for Treatment of Signs and Symptoms in Individuals with Mild, Moderate, and Severe Dry Eye Disease. Clin Ther. 2022;44(11):1463-1470. doi:10.1016/j.clinthera.2022.09.013

Sheppard J, Shen Lee B, Periman LM. Dry eye disease: identification and therapeutic strategies for primary care clinicians and clinical specialists. Ann Med. 2023;55(1):241-252. doi:10.1080/07853890.2022.2157477

Gupta PK, Periman LM, Lain E, et al. Meibomian Gland Dysfunction: A Dermatological Perspective on Pathogenesis and Treatment Outlook. Clin Ophthalmol. 2021;15:4399-4404. Published 2021 Nov 9. doi:10.2147/OPTH.S327407

Aninye IO, Digre K, Hartnett ME, et al. The roles of sex and gender in women's eye health disparities in the United States. Biol Sex Differ. 2021;12(1):57. Published 2021 Oct 20. doi:10.1186/s13293-021-00401-3

Periman LM, Mah FS, Karpecki PM. A Review of the Mechanism of Action of Cyclosporine A: The Role of Cyclosporine A in Dry Eye Disease and Recent Formulation Developments. Clin Ophthalmol. 2020;14:4187-4200. Published 2020 Dec 2. doi:10.2147/OPTH.S279051

Epitropoulos AT, Therattil A, Periman LM, Rosenberg ED. Improving Tolerance and Compliance with Topical Immunomodulators Using Micro-Emulsion Lipid Layer Artificial Tears. Clin Ophthalmol. 2020;14:1921-1929. Published 2020 Jul 6. doi:10.2147/OPTH.S258983

Periman LM, Perez VL, Saban DR, Lin MC, Neri P. The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options. J Ocul Pharmacol Ther. 2020;36(3):137-146. doi:10.1089/jop.2019.0060

Fishman HA, Periman LM, Shah AA. Real-Time Video Microscopy of In Vitro Demodex Death by Intense Pulsed Light. Photobiomodul Photomed Laser Surg. 2020;38(8):472-476. doi:10.1089/photob.2019.4737

Periman LM, Ambrosio R Jr, Harrison DA, Wilson SE. Correlation of pupil sizes measured with a mesopic infrared pupillometer and a photopic topographer. J Refract Surg. 2003;19(5):555-559. doi:10.3928/1081-597X-20030901-10

Periman LM, Harrison DA, Kim J. Fungal keratitis after photorefractive keratectomy: delayed diagnosis and treatment in a co-managed setting. J Refract Surg. 2003;19(3):364-366. doi:10.3928/1081-597X-20030501-15

Ambrósio R Jr, Periman LM, Netto MV, Wilson SE. Bilateral marginal sterile infiltrates and diffuse lamellar keratitis after laser in situ keratomileusis. J Refract Surg. 2003;19(2):154-158. doi:10.3928/1081-597X-20030301-11

Periman LM, Sires BS. Floppy eyelid syndrome: a modified surgical technique. Ophthalmic Plast Reconstr Surg. 2002;18(5):370-372. doi:10.1097/00002341-200209000-00009

Harrison DA, Periman LM. Diffuse lamellar keratitis associated with recurrent corneal erosions after laser in situ keratomileusis. J Refract Surg. 2001;17(4):463-465. doi:10.3928/1081-597X-20010701-09

Periman LM, Sires BS. Full-thickness skin grafting of eyelids in a patient with generalized morphea taking thalidomide. Arch Ophthalmol. 2000;118(1):135-136.

Kaynard AH, Periman LM, Simard J, Melner MH. Ovarian 3 beta-hydroxysteroid dehydrogenase and sulfated glycoprotein-2 gene expression are differentially regulated by the induction of ovulation, pseudopregnancy, and luteolysis in the immature rat. Endocrinology. 1992;130(4):2192-2200. doi:10.1210/endo.130.4.1547735

Simard J, Melner MH, Breton N, et al. Characterization of macaque 3 beta-hydroxy-5-ene steroid dehydrogenase/delta 5-delta 4 isomerase: structure and expression in steroidogenic and peripheral tissues in primate. Mol Cell Endocrinol. 1991;75(2):101-110. doi:10.1016/0303-7207(91)90224-g